Advanced Regenerative Wound Care Solutions.

NanoEx Interactive Regenerating Wound Dressing Matrix

Advanced Regenerating Dermal Matrix for Soft Tissue Repair.

NanoEx® Interactive Regenerating Wound Dressing Matrix is an advanced wound care solution designed to support tissue repair through a combination of structural support, optimized wound environment management, ECM-mimetic composition and antibacterial protection.

CE-marked since 05/2021 and manufactured under an ISO 13485-certified quality management system, NanoEx is developed for integration into modern wound care protocols where effective interaction with the wound bed and support of physiological healing processes are essential.

NanoEx is provided as a pre-formed, sterile dermal matrix intended for direct application to the wound bed, offering immediate coverage and structural support.

Mechanism of Action

Upon application, NanoEx functions as a pre-structured three-dimensional matrix that interacts with the wound environment to establish a stable, porous, and moisture-permeable scaffold.

• Conforms closely to the wound surface, including irregular geometries
• Maintains consistent contact with the wound bed
• Supports an optimized moist wound environment when used with appropriate secondary dressings
• Provides a physical ECM-mimetic scaffold that supports cellular migration, proliferation and tissue formation
• Contributes to modulation of the wound microenvironment toward a regenerative profile
• Supports fibroblast and endothelial cell activity associated with tissue repair
• Encourages formation of vascularized granulation tissue
• Provides antibacterial and anti-biofilm functionality within the wound environment
• Facilitates the progression of the wound healing process toward tissue repair

The dermal matrix is designed to mimic key structural characteristics of the extracellular matrix (ECM), creating a supportive microenvironment conducive to granulation tissue formation and progressive tissue remodeling. It helps facilitate transition from prolonged inflammatory conditions toward healing progression.

Clinical Advantages and Properties

• Advanced wound care dermal matrix with interactive functionality
• Provides immediate structural scaffold upon application
• Biocompatible and designed for tissue compatibility
• Moisture-vapor permeable
• Porous, breathable, and transparent structure
• Supports pH regulation within the wound environment
• Conforms to wound surface and complex anatomies
• Flexible and adaptable to wound contours
• Supports use across different stages of wound healing
• Supports efficient wound healing progression
• Demonstrated contribution to improved healing outcomes, including reduced healing time and minimized scar formation when used appropriately
• Suitable for application over exposed tendons and bones
• Can be used over joints without restricting mobility
• Painless and non-traumatic application

Indications

NanoEx is indicated for the management of:

• Partial and full-thickness wounds
• Diabetic foot ulcers
• Pressure ulcers
• Burn wounds
• Traumatic wounds
• Surgical wounds
• Infected and non-infected wounds
• Skin grafts and donor sites
• Wounds with exposed tendons and bones
• Cavity wounds
• Dry wounds and wounds with low to moderate exudation

Unlike absorbent wound dressings, NanoEx is non-exudate absorbing and is intended to function as a regenerative scaffold rather than a fluid management solution. Appropriate superabsorbent secondary dressings or combination with Negative Pressure Wound Therapy (NPWT) should be used to manage exudate when necessary.

The matrix is biocompatible, moisture-permeable, and engineered to support an optimal regenerative microenvironment.

Packaging

• 10 x 10 cm, cuttable to the shape of the wound.
• Provided sterile in primary packaging and sealed within a sterile secondary pouch.

NanoEx+ ECM-mimetic Dermal Regenerating Matrix

NanoEx+ ECM-mimetic Dermal Regenerating Matrix is an active regenerative wound therapy developed through years of research and patented innovations. Using proprietary AKTISCHICHT® technology and specialized expertise, NanoEx+ is engineered as a dermal matrix composed of micronized ECM and ECM-mimetic components in a clinically optimized scaffold for soft tissue repair and regeneration.

Mechanism of Action

NanoEx+ ECM-mimetic Dermal Regenerating Matrix is applied to a properly prepared wound following standard wound bed preparation principles. As a pre-structured matrix, NanoEx+ provides an immediate three-dimensional scaffold upon application. When in contact with the wound environment and exudation, it integrates with the wound bed and establishes a stable, porous, breathable, and transparent matrix.

• Conforms to the wound surface architecture
• Ensures consistent contact with the wound bed
• Maintains an optimized moist wound environment in conjunction with appropriate secondary dressings
• Supports physiological wound healing processes
• Exhibits anti-inflammatory properties and helps reduce excessive pro-inflammatory activity
• Promotes a shift toward a pro-remodeling macrophage profile
• Facilitates transition from chronic inflammation to regenerative healing
• Supports migration of fibroblasts and endothelial cells
• Promotes vascular ingrowth, including over poorly perfused or avascular structures
• Encourages development of a vascularized wound environment conducive to closure
• Provides antibacterial and anti-biofilm activity within the wound environment

Clinical Advantages and Properties

• Active regenerative wound therapy
• Anti-inflammatory properties
• Antiseptic and anti-biofilm activity
• Supports optimized wound healing environment
• Biocompatible
• Moisture-vapor permeable
• Porous, breathable, and transparent structure
• Conforms to wound surface and irregular geometries
• Provides immediate structural scaffold
• Flexible and adaptable to wound contours
• Suitable for all phases of wound healing
• Supports reduction in healing time
• Helps reduce scar tissue formation
• Applicable on exposed tendons and bones
• Suitable for use over joints without restricting movement
• Painless application

Indications

• Partial and full-thickness wounds
• Diabetic foot ulcers
• Pressure ulcers
• Burn wounds
• Traumatic wounds
• Surgical wounds
• Infected and non-infected wounds
• Venous ulcers
• Skin grafts and donor sites
• Wounds with exposed tendons and bones
• Cavity wounds
• Dry wounds and wounds with low to moderate exudation

Advanced Bioactive Composition

NanoEx+ ECM-mimetic Dermal Regenerating Matrix consists primarily of vegan and synthetic components. The only animal-derived ingredient is premium medical-grade collagen, selected for its structural integrity and compatibility in wound healing applications.

Unlike absorbent wound dressings, NanoEx+ is non-exudate absorbing and is intended to function as a regenerative scaffold rather than a fluid management solution. Appropriate superabsorbent secondary dressings or combination with Negative Pressure Wound Therapy should be used to manage exudate when necessary.

Packaging

Available in sterile formats as primary packaging, sealed in a sterile pouch as secondary packaging.

AktivDerm Powdered ECM-mimetic Dermal Regenerating Matrix

AktivDerm Powdered ECM-mimetic Dermal Regenerating Matrix is an active regenerative wound therapy developed through years of research and patented innovations. Using proprietary AKTISCHICHT® technology and specialized know-how, we manufacture a super-absorptive sterile dry powder composed of several micronized ECM or ECM-mimetic components in a specific clinically proven composition intended for soft tissue repair and regeneration.

The powder is specifically engineered to access hard-to-reach cavity and tunneling wounds and to maximize contact with irregular wound beds, areas where traditional sheet, foam, or gel dressings may have limitations.

Mechanism of Action

Upon contact with wound exudate, the sterile dry powder transforms within minutes into a conforming wound covering. For dry wounds, the powder can be hydrated with normal saline directly in the wound bed or in a sterile tray prior to application.

• Conforms precisely to the wound architecture
• Maximizes contact with the entire wound surface
• Maintains an optimized moisture balance
• Supports physiological wound healing processes
• Has anti-inflammatory properties and reduces excessive pro-inflammatory activity
• Supports a shift toward a pro-remodeling macrophage profile
• Transits from chronic inflammatory state to regenerative healing phase
• Enables rapid migration of fibroblasts and endothelial cells
• Promotes vascular ingrowth, including over poorly perfused or avascular structures
• Accelerates development of a vascularized wound environment conducive to closure
• Has antibacterial and anti-biofilm activity within the wound environment

Clinical Advantages and Properties

• Active regenerative wound therapy
• Anti-inflammatory properties
• Antiseptic and anti-biofilm properties
• Optimizing moisture and pH of the wound bed
• Porous, breathable and 100% transparent
• Access hard-to-reach cavity or tunneling wounds
• Maximize contact with irregular wound beds
• Flexible and adjustable to the shape of the wound bed
• Usable in all phases of wound healing
• Biocompatible and super-absorptive in wound bed
• Absorbs excessive exudate in moderately to highly exuding wounds
• Moisture-vapor permeable
• Significant reduction of wound healing time
• Reduction of scar tissue formation
• Applicable on exposed tendons and bones
• Applicable on joints without restricting joint movement
• Painless application and no need to change

Indications

• Cavity wounds
• Tunneling and undermined wounds
• Partial and full-thickness wounds
• Burn wounds
• Traumatic wounds
• Surgical wounds
• Infected and non-infected wounds
• Diabetic foot ulcers
• Pressure ulcers
• Skin grafts and donor sites
• Exposed tendons and bones
• Venous ulcers

Unlike passive absorbent dressings that serve primarily as coverage, AktivDerm Powdered ECM-mimetic Dermal Regenerating Matrix forms an in situ regenerative scaffold that actively participates in the wound healing environment.

Packaging

Available in sterile vials as primary packaging of 1 gram, 2 grams, 5 grams, and 10 grams, sealed sterile in a single pouch as secondary packaging.

AktivDerm Spray ECM-mimetic Dermal Regenerating Matrix

Spray ECM-mimetic Dermal Regenerating Matrix is an active regenerative wound therapy developed through years of research and patented innovations. Using proprietary AKTISCHICHT® technology and specialized know-how, we manufacture a sterile sprayable ECM-mimetic formulation composed of several ECM or ECM-mimetic components in a specific clinically proven composition intended for soft tissue repair and regeneration.

The spray formulation is specifically engineered for rapid and uniform application across large wound surfaces, irregular wound geometries, difficult anatomical areas, and sensitive wounds where direct contact with conventional dressings may be challenging. It enables non-contact application while maximizing coverage of the wound bed.

Mechanism of Action

The sterile spray formulation is sprayed directly onto the wound bed from an appropriate distance to ensure uniform distribution across the entire wound surface. Upon contact with the wound environment, the sprayed formulation rapidly forms a conforming wound covering that adapts to the wound architecture.

• Conforms precisely to the wound architecture
• Maximizes contact with the entire wound surface
• Maintains an optimized moisture balance
• Supports physiological wound healing processes
• Has anti-inflammatory properties and reduces excessive pro-inflammatory activity
• Supports a shift toward a pro-remodeling macrophage profile
• Transits from chronic inflammatory state to regenerative healing phase
• Enables rapid migration of fibroblasts and endothelial cells
• Promotes vascular ingrowth, including over poorly perfused or avascular structures
• Accelerates development of a vascularized wound environment conducive to closure
• Has antibacterial and anti-biofilm activity within the wound environment

Clinical Advantages and Properties

• Active regenerative wound therapy
• Anti-inflammatory properties
• Antiseptic and anti-biofilm properties
• Optimizes moisture and pH balance of the wound bed
• Porous, breathable and transparent protective matrix formation
• Non-contact application for sensitive wounds
• Uniform coverage of large wound surfaces
• Access difficult anatomical locations
• Flexible and adaptable to wound contours
• Usable in all phases of wound healing
• Biocompatible and highly absorptive within the wound bed
• Supports management of exudating wounds
• Moisture-vapor permeable
• Significant reduction in wound healing time
• Reduction of scar tissue formation
• Applicable on exposed tendons and bones
• Applicable on joints without restricting movement
• Painless application with minimal wound disturbance

Indications

• Partial and full-thickness wounds
• Irregular surface wounds
• Large-area wounds
• Burn wounds
• Traumatic wounds
• Surgical wounds
• Infected and non-infected wounds
• Diabetic foot ulcers
• Pressure ulcers
• Skin grafts and donor sites
• Exposed tendons and bones
• Venous ulcers

Unlike passive absorbent dressings that serve primarily as coverage, Spray ECM-mimetic Dermal Regenerating Matrix forms an in situ regenerative scaffold that actively participates in the wound healing environment.

Packaging

Available in sterile spray containers as primary packaging and sealed sterile in individual secondary packaging.

COLTIX® Bioactive Rapid Hemostatic Powder

Rapid Hemostasis. Infection Protection. Ready When Seconds Matter.

Every year, millions of people around the world are affected by hemorrhage-related injuries, both in civilian and military settings. According to global health statistics, trauma-induced bleeding accounts for nearly 10% of deaths annually, and approximately 40% of traumatic cases lead to death within 24 hours due to uncontrollable hemorrhage, coagulopathy, or incomplete resuscitation. The Centers for Disease Control and Prevention ranks posttraumatic hemorrhage as the fourth leading cause of mortality in the United States.

In many battlefields and emergency scenarios, nearly 60% of preventable deaths occur because of hemorrhage before proper medical assistance can be provided. Ineffective prehospital bleeding control frequently leads to severe blood loss and acute coagulopathy among trauma victims, conditions responsible for one-third of all related hospital admissions.

COLTIX® is a next generation ready-to-use, bioactive biocompatible hemostatic powder designed for rapid bleeding control in emergency, surgical, trauma, and field-care settings. The powder rapidly adheres to wet tissue to support fast hemostasis while offering additional antimicrobial and anti-inflammatory benefits that may help reduce complications associated with contaminated wounds such as delayed healing, limb amputation, or increased mortality.

Its biodegradable formulation is engineered to provide fast, reliable bleeding control while supporting safer wound management in critical situations where immediate intervention is essential. COLTIX® is manufactured under strict quality control in a cleanroom environment compliant with ISO 13485 standards, utilizing only medical-grade raw materials.

Key Benefits

• Rapid bleeding control by activating and supporting both the intrinsic and extrinsic pathways of the coagulation cascade
• Strong adherence to wet tissue surfaces
• Superior absorption capacity of 9–10 times its own weight
• Antimicrobial support
• Anti-inflammatory properties
• Biodegradable formulation
• Sterile packaging
• Easy and fast application

Intended Use Settings

• Emergency medicine
• Trauma care
• Surgical procedures
• Military and battlefield care
• First response applications

PHMB Wound Irrigation Spray

Sterile Antimicrobial Solution for Wound Cleansing and Irrigation.

A sterile, ready-to-use wound irrigation solution containing polyhexamethylene biguanide (PHMB), designed to provide broad-spectrum antimicrobial action, biofilm control, and support of physiological wound healing and intended for the cleansing, irrigation, and moistening of all types of both acute and chronic wounds.

The product is designed to reduce microbial load and inhibit biofilm formation, thereby supporting the wound healing process.

Mechanism of Action

PHMB is a cationic polymer that interacts selectively with negatively charged microbial cell membranes. Its mechanism includes disruption of bacterial cell membrane integrity, increased permeability with leakage of intracellular components, binding to microbial DNA with inhibition of replication, and rapid microbial cell death.

PHMB demonstrates broad-spectrum antimicrobial activity, including:

• Gram-positive bacteria
• Gram-negative bacteria
• Fungi
• Biofilm-associated microorganisms commonly implicated in chronic wounds

Anti-Biofilm Activity

PHMB has demonstrated the ability to penetrate and disrupt biofilms, including extracellular polymeric substances (EPS), which protect bacteria from host defenses and antimicrobial agents.

Effects on Wound Healing Environment

• Reduction of microbial burden
• Maintenance of a clean wound environment
• High tissue compatibility with low cytotoxicity at clinical concentrations
• Improved conditions for granulation and epithelialization
• Reduced risk of infection-related complications

Inflammation and Pain

PHMB is still not classified as an anti-inflammatory or analgesic agent. However, clinical evidence indicates that reduction of microbial load may decrease local inflammatory responses and patients may experience reduced wound-associated pain as a secondary outcome of infection control and improved wound conditions. These effects should be considered indirect and supportive, not primary pharmacological actions.

Safety and Biocompatibility

• PHMB exhibits low cytotoxicity toward human keratinocytes and fibroblasts at clinically used concentrations.
• Suitable for repeated application and prolonged use.
• Generally well tolerated in wound care applications.

Comparative Positioning