The global burden of acute and chronic wounds continues to grow and remains a significant challenge for healthcare systems worldwide. Population aging, increasing rates of diabetes, vascular disease, obesity, trauma injuries, burns, and surgical procedures have contributed to a rising number of patients requiring advanced wound management solutions. According to the International Diabetes Federation (IDF), approximately 537 million adults worldwide were living with diabetes in 2021, and this number is projected to increase in the coming decades. Diabetic foot complications remain among the most serious consequences of diabetes, and published studies estimate that approximately 19–34% of individuals with diabetes may develop a diabetic foot ulcer during their lifetime. In addition to diabetic wounds, millions of patients worldwide are affected annually by:
• pressure injuries
• venous leg ulcers
• traumatic wounds
• burn injuries
• surgical wounds
• soft tissue defects

Many complex wounds are associated with prolonged inflammation, elevated exudate levels, impaired tissue regeneration, microbial burden, and challenging wound geometries that may limit the effectiveness of conventional wound management approaches. These wounds can lead to prolonged treatment durations, increased healthcare utilization, and significant impacts on patient quality of life.