AktivDerm Powdered ECM-mimetic Dermal Regenerating Matrix should be applied to a properly prepared wound following standard wound bed preparation principles

Upon contact with wound exudate, the sterile dry powder transforms within minutes into a conforming wound covering. For dry wounds, the powder can be hydrated with normal saline directly in the wound bed or in a sterile tray prior to application.

Following hydration, AktivDerm Powdered ECM-mimetic Dermal Regenerating Matrix forms a porous, breathable, transparent three-dimensional matrix structure that:

• Conforms precisely to the wound architecture
• Maximizes contact with the entire wound surface
• Maintains an optimized moisture balance
• Supports physiological wound healing processes
• Has antiinflammatory properties and reduces the excessive pro-inflammatory activity
• Supports a shift toward a pro-remodeling (M2-dominant) macrophage profile
• Transits from chronic inflammatory state to regenerative healing phase  
• Enables rapid migration of fibroblasts and endothelial cells
• Promotes vascular ingrowth, including over poorly perfused or avascular structures
• Accelerates development of a vascularized wound environment conducive to closure
• Has antibacterial and anti-biofilm activity within the wound environment

This structured 3D matrix may be considered an artificial extracellular matrix (ECM)-like scaffold designed to create an optimized microenvironment that supports cellular migration, granulation tissue formation, and progressive tissue remodeling and reconstruction.

By helping disrupt biofilm presence and supporting balanced immune modulation, AktivDerm Powdered ECM-mimetic Dermal Regenerating Matrix promotes accelerated wound area reduction and improved quality of tissue regeneration.

The amount of powder required depends on wound size, depth, and level of exudate.

You can place this under your Mechanism of Action section.