Mechanism of Action
NanoEx+ ECM-mimetic Dermal Regenerating Matrix is applied to a properly prepared wound following standard wound bed preparation principles.
As a pre-structured matrix, NanoEx+ provides an immediate three-dimensional scaffold upon application. When in contact with the wound environment and exudation, it integrates with the wound bed and establishes a stable, porous, breathable, and transparent matrix that:
• Conforms to the wound surface architecture
• Ensures consistent contact with the wound bed
• Maintains an optimized moist wound environment (in conjunction with appropriate secondary dressings)
• Supports physiological wound healing processes
• Exhibits anti-inflammatory properties and helps reduce excessive pro-inflammatory activity
• Promotes a shift toward a pro-remodeling (M2-dominant) macrophage profile
• Facilitates transition from chronic inflammation to regenerative healing
• Supports migration of fibroblasts and endothelial cells
• Promotes vascular ingrowth, including over poorly perfused or avascular structures
• Encourages development of a vascularized wound environment conducive to closure
• Provides antibacterial and anti-biofilm activity within the wound environment
This structured matrix functions as an artificial extracellular matrix (ECM)-like scaffold, designed to create an optimized microenvironment that supports cellular migration, granulation tissue formation, and progressive tissue remodeling.
By supporting immune balance and disrupting biofilm presence, NanoEx+ contributes to accelerated wound closure and improved tissue regeneration quality.
Clinical Advantages and Properties
• Active regenerative wound therapy
• Anti-inflammatory properties
• Antiseptic and anti-biofilm activity
• Supports optimized wound healing environment
• Biocompatible
• Moisture-vapor permeable
• Porous, breathable, and transparent structure
• Conforms to wound surface and irregular geometries
• Provides immediate structural scaffold
• Flexible and adaptable to wound contours
• Suitable for all phases of wound healing
• Supports reduction in healing time
• Helps reduce scar tissue formation
• Applicable on exposed tendons and bones
• Suitable for use over joints without restricting movement
• Painless application
NanoEx+ ECM-mimetic Dermal Regenerating Matrix
A Regenerative ECM Approach of AKTISCHICHT® to Wound Healing
NanoEx+ provides a pre-formed, structured three-dimensional ECM-mimetic dermal matrix that creates a controlled and optimized wound microenvironment immediately upon application.
Its advanced bioactive composition, structural integrity, and scaffold functionality position NanoEx+ as a next-generation solution in regenerative wound therapy. The matrix format ensures consistent coverage, stability, and effective support for tissue regeneration across a wide range of wound types, particularly where structural support is preferred over absorbent functionality.
Indications
NanoEx+ ECM-mimetic Dermal Regenerating Matrix is suitable for a wide range of acute and chronic wounds, including:
• Partial and full-thickness wounds
• Diabetic foot ulcers (DFU)
• Pressure ulcers (decubitus/bedsores)
• Burn wounds
• Traumatic wounds
• Surgical wounds
• Infected and non-infected wounds
• Venous ulcers
• Skin grafts and donor sites
• Wounds with exposed tendons and bones
• Cavity wounds
• Dry wounds and wounds with low to moderate exudation (wound discharge)
Advanced Bioactive Composition
NanoEx+ ECM-mimetic Dermal Regenerating Matrix consists primarily of vegan and synthetic components. The only animal-derived ingredient is premium medical-grade collagen, selected for its structural integrity and compatibility in wound healing applications.
The formulation is designed to:
• Provide structural matrix support within the wound bed
• Interact dynamically with the wound environment
• Gradually release functional materials into the wound site
• Help maintain optimal moisture and physiological pH conditions
• Support a balanced inflammatory response
• Deliver antibacterial and anti-biofilm activity
Unlike absorbent wound dressings, NanoEx+ is non-exudate absorbing and is intended to function as a regenerative scaffold rather than a fluid management solution. Appropriate superabsorbent secondary dressings or combination with Negative Pressure Wound Therapy (NPWT) should be used to manage exudate when necessary.
Its structure enables uniform coverage across the wound surface, including complex and irregular geometries, while maintaining stability throughout the healing process.
The matrix is biocompatible, moisture-permeable, and engineered to support an optimal regenerative microenvironment.
Packaging
Available in sterile formats (primary packaging), sealed in a sterile pouch (secondary packaging).