Mechanism of Action
In Situ Transformation into a 3D Regenerative ECM-mimetic Dermal Matrix
AktivDerm Powdered ECM-mimetic Dermal Regenerating Matrix should be applied to a properly prepared wound following standard wound bed preparation principles. Upon contact with wound exudate, the sterile dry powder transforms within minutes into a conforming wound covering. For dry wounds, the powder can be hydrated with normal saline directly in the wound bed or in a sterile tray prior to application.
Following hydration, AktivDerm Powdered ECM-mimetic Dermal Regenerating Matrix forms a porous, breathable, transparent three-dimensional matrix structure that:
• Conforms precisely to the wound architecture
• Maximizes contact with the entire wound surface
• Maintains an optimized moisture balance
• Supports physiological wound healing processes
• Has anti-inflammatory properties and reduces the excessive pro-inflammatory activity
• Supports a shift toward a pro-remodeling (M2-dominant) macrophage profile
• Transits from chronic inflammatory state to regenerative healing phase
• Enables rapid migration of fibroblasts and endothelial cells
• Promotes vascular ingrowth, including over poorly perfused or avascular structures
• Accelerates development of a vascularized wound environment conducive to closure
• Has antibacterial and anti-biofilm activity within the wound environment
This structured 3D matrix may be considered an artificial extracellular matrix (ECM)-like scaffold designed to create an optimized microenvironment that supports cellular migration, granulation tissue formation, and progressive tissue remodeling and reconstruction.
By helping disrupt biofilm presence and supporting balanced immune modulation, AktivDerm Powdered ECM-mimetic Dermal Regenerating Matrix promotes accelerated wound area reduction and improved quality of tissue regeneration.
The amount of powder required depends on wound size, depth, and level of exudate.
Clinical Advantages and Properties
• Active regenerative wound therapy
• Anti-inflammatory properties
• Antiseptic and anti-biofilm properties
• Optimizing moisture and pH of the wound bed
• Porous, breathable, and 100% transparent
• Access hard-to-reach cavity or tunneling wounds
• Maximize contact with irregular wound beds
• Flexible and adjustable to the shape of the wound bed
• Usable in all phases of wound healing
• Biocompatible and super-absorptive in the wound bed
• Absorbs excessive exudate in moderately to highly exuding wounds
• Moisture-vapor permeable
• Significant reduction of wound healing time
• Reduction of scar tissue formation
• Applicable on exposed tendons and bones
• Applicable on joints without restricting movement
• Painless application and no need to change
Indications
AktivDerm Powdered ECM-mimetic Dermal Regenerating Matrix is suitable for a broad spectrum of acute and chronic wounds, including:
• Cavity wounds
• Tunneling and undermined wounds
• Partial and full-thickness wounds
• Burn wounds
• Traumatic wounds
• Surgical wounds
• Infected and non-infected wounds
• Diabetic foot ulcers (DFU)
• Decubitus / bedsores / pressure ulcers
• Skin grafts and donor sites
• Exposed tendons and bones
• Venous ulcers
Unlike passive absorbent dressings that serve primarily as coverage, AktivDerm Powdered ECM-mimetic Dermal Regenerating Matrix forms an in situ regenerative scaffold that actively participates in the wound healing environment. Its conformability and scaffold- forming properties allow uniform distribution throughout complex wound geometries, including undermined and irregular spaces.
The resulting matrix is biocompatible, super-absorptive, moisture-vapor permeable, and engineered to support an optimal healing microenvironment.
Packaging
Available in sterile vials (primary packaging) of:
• 1 gram
• 2 grams
• 5 grams
• 10 grams
sealed sterile in a single pouch (secondary packaging).