Mechanism of Action
NanoEx+ ECM-mimetic Dermal Regenerating Matrix is applied to a properly prepared wound following standard wound bed preparation principles.
In Situ Formation of a 3D Regenerative ECM-mimetic Dermal Matrix Spray ECM-mimetic Dermal Regenerating Matrix should be applied to a properly prepared wound following standard wound bed preparation principles. The sterile spray formulation is sprayed directly onto the wound bed from an appropriate distance to ensure uniform distribution across the entire wound surface.
Upon contact with the wound environment, the sprayed formulation rapidly forms a conforming wound covering that adapts to the wound architecture.
Following application, Spray ECM-mimetic Dermal Regenerating Matrix forms a porous, breathable, transparent three-dimensional matrix structure that:
• Conforms precisely to the wound architecture
• Maximizes contact with the entire wound surface
• Maintains an optimized moisture balance
• Supports physiological wound healing processes
• Has anti-inflammatory properties and reduces excessive pro-inflammatory activity
• Supports a shift toward a pro-remodeling (M2-dominant) macrophage profile
• Transits from chronic inflammatory state to regenerative healing phase
• Enables rapid migration of fibroblasts and endothelial cells
• Promotes vascular ingrowth, including over poorly perfused or avascular structures
• Accelerates development of a vascularized wound environment conducive to closure
• Accelerates development of a vascularized wound environment conducive to closure
This structured 3D matrix may be considered an artificial extracellular matrix (ECM)-like scaffold designed to create an optimized microenvironment that supports cellular migration, granulation tissue formation, and progressive tissue remodeling and reconstruction.
By helping disrupt biofilm presence and supporting balanced immune modulation, Spray ECM-mimetic Dermal Regenerating Matrix promotes accelerated wound area reduction and improved quality of tissue regeneration.
The amount of spray required depends on wound size, depth, and wound condition.
Packaging
Available in sterile spray containers (primary packaging)
Sealed sterile in individual secondary packaging
Indications
AktivDerm Spray ECM-mimetic Dermal Regenerating Matrix is suitable for a broad spectrum of acute and chronic wounds, including:
• • Partial and full-thickness wounds
• Irregular surface wounds
• Large-area wounds
• Burn wounds
• Traumatic wounds
• Surgical wounds
• Infected and non-infected wounds
• Diabetic foot ulcers (DFU)
• Decubitus / bedsores / pressure ulcers
• Skin grafts and donor sites
• Exposed tendons and bones
• Venous ulcers
Unlike passive absorbent dressings that serve primarily as coverage, Spray ECM-mimetic Dermal Regenerating Matrix forms an in situ regenerative scaffold that actively participates in the wound healing environment.
Its spray delivery system enables fast, even distribution across complex wound surfaces while forming a protective regenerative matrix.
The resulting matrix is biocompatible, breathable, moisture-vapor permeable, and engineered to support an optimal healing microenvironment.
Clinical Advantages and Properties
• Active regenerative wound therapy
• Anti-inflammatory properties
• Antiseptic and anti-biofilm properties
• Optimizes moisture and pH balance of the wound bed
• Porous, breathable and transparent protective matrix formation
• Non-contact application for sensitive wounds
• Uniform coverage of large wound surfaces
• Access difficult anatomical locations
• Flexible and adaptable to wound contours
• Usable in all phases of wound healing
• Biocompatible and highly absorptive within the wound bed
• Supports management of exudating wounds
• Moisture-vapor permeable
• Significant reduction in wound healing time
• Reduction of scar tissue formation
• Applicable on exposed tendons and bones
• Applicable on joints without restricting movement
• Painless application with minimal wound disturbance